Abstract

TASSIN, Mauro; LLARENA, Pablo; LAFFAYE, Federico  and  KALTENBACH, Germán. Protein C deficiency in patient with sepsis-associated disseminated intravascular coagulation and deep vein thrombosis. Arch. argent. pediatr. [online]. 2013, vol.111, n.1, pp.e28-e30. ISSN 0325-0075.

Disseminate intravascular coagulation (DIC) is a clinical pathological syndrome associated to several diseases. Sepsis is the most common cause in infants and children. DIC results from the anomalous activation of blood coagulation, widespread formation of thrombi in the microcirculation, and consumption of clotting factors and platelets. Clinical findings are variable; the most common is bleeding, followed by purpura and acral gangrene (purpura fulminans). We report a patient with sepsis associated-DIC and concurrent deep venous thrombosis. The diagnostic evaluation allowed to discover inherited thrombophilia associated to protein C deficiency.

Keywords : Sepsis; Disseminate intravascular coagulation; Deep venous thrombosis; Protein C deficiency.

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