Abstract

NAVARRO-HERNANDEZ, Rosa Elena; VAZQUEZ-DEL MERCADO, Mónica; OREGON-ROMERO, Edith  and  MUNOZ-VALLE, José Francisco. Single nucleotid polymorphisms of adhesion molecules and clinical parameters in rheumatoid arthritis. Acta bioquím. clín. latinoam. [online]. 2007, vol.41, n.2, pp.193-202. ISSN 0325-2957.

The genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) technique. The ESR (erythrocyte sedimentation rate), RF (rheumatoid factor), fibrinogen (FB), C-reactive protein (CRP) and lipid profile were measured by routine methods. Statistical analysis was performed using SPSS v10.0. The significant Pearson´s correlations were: ESR with CRP, RF, FB and HDLc, (r=0.507, 0.296, 0.475, and -0.308, respectively); CRP with FB (r=0.613), p<0.05. The results showed an association with A allele of ICAM1 polymorphism and serum levels of HDLc and LDLc; and Apo-B and FR showed an association with C allele of VCAM1 polymorphism (p<0.05). Data shows that FB and HDLc levels, and ICAM1 polymorphism allele 721A and VCAM1 polymorphism allele 1238G are associated with clinical inflammation markers in RA. Our Mexican-mestizo population showed differences with many reports (from English, American, Turkish, Japanese, Chinese, Italian, and Korean populations).

Keywords : adhesion molecules; single nucleotide polymorphisms; rheumatoid arthritis; hight density lipoprotein cholesterol; low density lipoprotein cholesterol; fibrinogen; C reactive protein; rheumatoid factor.

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