Abstract

AGUILAR, Daniel et al. Apolipoprotein C-III and E concentrations in patients with coronary atherosclerotic disease. Acta bioquím. clín. latinoam. [online]. 2010, vol.44, n.2, pp.171-177. ISSN 0325-2957.

Apo C-III and E serum concentrations were evaluated in patients with coronary atherosclerotic disease (CAD) diagnosed by angiography. Out of 226 individuals under angiographic study, Apo C-III and E were measured by immunoturbidimetric method developed in the laboratory in 148 patients with CAD. An Apo C-III serum concentration was 9.8±4.5 mg/dL in CAD and 9.1±4.1 mg/dL in non-CAD (p:0.25). Triglyceride concentrations were 168±83 mg/dL in CAD people. Apo E concentration was 6.0±3,3 mg/dL, higher concentrations being in women (7.0±3.3 mg/dL) than in men (5.7±3.3 mg/dL), p:0.05. No differences were obtained according to the number of injured vessels. Serum concentrations of apo C-III and E in individuals with CAD were above the desirable one proposed of 8.5 mg/dL and 5 mg/dL, respectively. Apo C-III and apo E immunoturbidimetric methods are quick and direct and, especially apo C-III, is a potentially complementary test, as a marker of triglyceride-rich particles, in the profile of laboratory cardiovascular risk.

Keywords : Apolipoprotein C-III; Apolipoprotein E; Triglyceride rich lipoproteins; Triglycerides; Coronary atherosclerotic disease.

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