Abstract

LAGUARDE, Marina et al. Urinary Protein/Creatinine ratio and Albumin/Creatinine ratio in patients with systemic lupus erythematosus. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.1, pp.5-10. ISSN 0325-2957.

The objective of the present work was to analyze the correlation between: protein/creatinine ratio in first-morning urine and 24-hour urine protein (P/C-P24h), and albumin/creatinine ratio in first-morning urine and 24-hour urine albumin (A/C-A24h) in patients with Systemic Lupus Erythematosus, and to evaluate the influence of creatinine clearance (CrCl) on the P/C-P24h correlation.It was a prospective cross-sectional study in which 80 samples of 52 outpatients with lupus were studied between March 2013 and August 2014. They were evaluated by Spearman Correlation Coefficient (CCS), the P/C-P24h and A/C-A24h correlations in different ranges of proteinuria and the influence of ClCr on P/C-P24h.This study showed a good correlation P/C-P24h for P24h≥300 mg/24h and A/C-A24h for P24h<300 mg/24h. No influence of ClCr in the P/C-P24h correlation was observed. These results and those obtained by other authors support the use of the A/C to P24h<300 mg/24h ratio and P/C to P24h≥300 mg/24h ratio to monitor renal involvement in patients with systemic lupus erythematosus using the first-morning urine.

Keywords : Protein/Creatinine ratio; Albumin/Creatinine ratio; Systemic lupus erythematosus.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )