Abstract

DUBOSCQ, Cristina; CERESETTO, José Manuel; ARIAS, Mirta  and  FORASTIERO, Ricardo. Diagnosis of acquired inhibitor against factor VIII. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.2, pp.223-232. ISSN 0325-2957.

The acquired inhibitor against factor VIII or “acquired haemophilia” (HA) is an autoimmune disease that usually appears as a sudden bleeding in patients without previos coagulopathy. Diagnosis of this disease must be quick, particularly when the presentation is a bleeding event that compromises the patient’s life. In this update, global and specific tests used in the detection of FVIII inhibitor are described. Besides, Nijmejen and Bethesda assays are analyzed for the quantification of the inhibitor to monitor treatment. The role of the laboratory is important in early diagnosis of this disease so the presence of this rare but life threatening disease must be suspected when a patient shows haemorrhages, prolonged aPTT that does not correct with normal plasma, decreased FVIII and a negative lupus anticoagulant test.

Keywords : Acquired haemophilia; Bleeding-diagnosis; Factor VIII; Bethesda; Nijmegen.

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