Abstract

MORALES SUAREZ, Carol et al. Leucocitary changes by ammonium perchlorate in ICR mice strain . Acta bioquím. clín. latinoam. [online]. 2018, vol.52, n.1, pp.79-87. ISSN 0325-2957.

The objective of this work was to identify the changes in the leukocyte counts in peripheral blood by ammonium perchlorate in ICR strain mice, evaluating the different exposure concentrations and differentiating the changes between males and females. Through an analytic experimental investigation, 60 ICR strain mice, 30 males and 30 females were used, 50 of which were exposed to ammonium perchlorate. This study was carried out by Resolution 008430/93, article 87 of Ministry of Health of Colombia. A total of 70% females and 83% males had changes in the leukocyte counts, especially lymphocytopenia in males, further, weight decreased the third week of treatment, and probably that toxic substance induces a state of immunosuppression. The main changes in the leukocyte counts in peripheral blood by ammonium perchlorate in ICR strain was leukopenia.

Keywords : Ammonium perchlorate; Leukocytes; Cellular immunity; Immunosuppression; Toxicity.

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