Abstract

VELASQUEZ, Jesús et al. Diagnostic value of lipid and anthropometric variables in metabolic dysfunctions. Acta bioquím. clín. latinoam. [online]. 2018, vol.52, n.3, pp.293-301. ISSN 0325-2957.

The objective of the study was to evaluate the performance of metabolic dysfunction index (MDI) detection constructed from the values of abdominal circumference, triglycerides and body mass index. A total of 829 subjects (327 males, 60.4±19.8 years), diagnosed with insulin resistance (IR) and metabolic syndrome according to the HOMA-IR, NCEP-ATP III (SM) and NCEP -ATP III revised (SM-R) criteria were studied. The area under the ROC curves (AUC), the optimal cut-off points (OCP), sensitivity (SEN), specificity (SPE), positive predictive value and negative predictive value (NPV) were used to evaluate the performance of the MDI. It was found that the MDI has an acceptable detection capacity since an AUC>0.75 was observed in all cases, and higher values (p<0.01) of MDI were found in the groups with SM, SM-R and IR compared to groups that do not suffer from the pathologies. Additionally, the OCPs for IR (MDI>21.01), SM (MDI>16.01) and SM-R (MDI>19.51) reported values of SPE, SEN, NPV greater than 0.70. Therefore, from an index composed of three variables taken from a routine medical study, two pathologies can be diagnosed that lead to the development of diabetes and cardiovascular diseases.

Keywords : Insulin resistance; Body mass index; Metabolic syndrome; HOMA-IR; ROC curves.

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