Abstract

MOTTA, Estela; CAPRISTO, Rocío  and  FRANCO, Micaela. Prevalence of anti-Saccharomyces cerevisiae antibodies in celiac patients. Acta bioquím. clín. latinoam. [online]. 2018, vol.52, n.4, pp.417-422. ISSN 0325-2957.

Celiac disease (CD) is a chronic inflammatory condition of the small intestine caused by gluten intolerance. The treatment consists of gluten free diet (GFD). Anti Saccharomyces cerevisiae antibodies (ASCA) are directed against the cell wall of yeast, associated with autoimmune diseases, and an altered intestinal permeability is proposed as a cause of activation of humoral immunity. The objective of this work was to determine the prevalence of IgG and IgA ASCA in celiac patients under treatment and to evaluate the association of ASCA with the degree of adherence to GFD. Fifty-nine serum samples from adult celiac patients with high or low adherence to GFD were analyzed, determining IgG and IgA ASCA. A 44% prevalence of IgG and/or IgA ASCA was found. An association was discovered between IgG ASCA and GFD adherence (OR 4.04, 95% CI: 1.32-12.38). The prevalence of ASCA in the studied celiac population is similar to that reported in the literature. The lower prevalence of IgG ASCA in patients with a strict GFD compared to those with low adherence would indicate that their presence depends on the level of gluten intake, suggesting them as a complementary tool in the follow-up of the celiac patient.

Keywords : Celiac disease; Anti Saccharomyces cerevisiae; Intestinal permeability; Gluten free diet.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )