Abstract

ULLOA LEON, Andrea; CRESPO PROANO, Carolina  and  CHIRIBOGA PONCE, Rosa F. Prevalencia de anticuerpos anti-eritrocitarios en donantes voluntarios de sangre Ecuatorianos. Acta bioquím. clín. latinoam. [online]. 2019, vol.53, n.3, pp.323-330. ISSN 0325-2957.

The screening of anti-erythrocyte antibodies is one of the most important pretransfusion tests in transfusion medicine because of its contribution to the prevention of adverse reactions after the administration of blood components, however not all blood banks in Ecuador have included this test in their work protocols. This study has the purpose to alert the national health system about the existence of alloimmunization in the blood donour population. A prevalence of anti-erythrocyte antibodies of 0.27% was established, with a higher frequency being found in the female gender. The identified antibodies are related to the erythrocyte systems Rh (RH), Kell (KEL), Duffy (FY) and Kidd (JK). One of the limitations for the inclusion of this test in blood banks and transfusion medicine services is the excessive cost of serological and gel methodology reagents, and the lack of homozygous and heterozygous erythrocyte cell panels for the identification of native anti-erythrocyte antibodies. That situation constitutes an opportunity for the Ministry of Public Health of Ecuador to promote better strategies for the imports of reagents, cost reduction and availability in the country.

Keywords : Blood donors; Anti-erythrocyte antibodies; Blood transfusion; Erythrocyte systems; Transfusion reactions; Pretransfusion tests.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )