Abstract

WIGDOROVITZ DE WIKINSKI, Regina Luisa; LOPEZ, Graciela  and  SCHREIER, Laura. Lipoproteínas ricas en triglicéridos y riesgo cardiovascular residual. Acta bioquím. clín. latinoam. [online]. 2022, vol.56, n.4, pp.427-432. ISSN 0325-2957.

Vast scientific evidence from clinical, preclinical, epidemiological, and genetic trial results show a causal association between increased triglycerides (TG), TG-rich lipoproteins (TRL), and their remnants for atherosclerotic cardiovascular disease (ASCVD). The accumulation of circulating LRT may explain, in part, the residual cardiovascular risk observed in patients successfully treated to reduce their LDL levels, however, the risk of ASCVD still persists. It is essential that in the assessment of the lipid profile, the determination or estimation of these lipoproteins be considered, added to the measurement of plasmatic TG. The objective of this review is to update the knowledge about the increased levels of TG, LRT and their remnants, proprovide alternatives for their determination and understand the mechanisms that involve LRT in the accelerated development of atherosclerosis. Updating the different parameters associated with increased TG and their cut-off values or clinical decision limits according to the ASCVD risk classification for each patient will allow for the redesign of a results report that will be very useful for the physician and the patient regarding the preventive and therapeutic behaviours of the ASCVD.

Keywords : Triglycerides; Residual risk; Remnant lipoproteins; Atherogenesis; Assesment by clinical laboratory.

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