Abstract

MARRADES, Carlos Ariel et al. Elementos esenciales y no esenciales en el hígado humano: un aporte para establecer valores de referencia de la región noroeste de la Argentina. Acta bioquím. clín. latinoam. [online]. 2023, vol.57, n.1, pp.17-23. ISSN 0325-2957.

In the health area it is necessary to know the reference range of trace elements of a healthy human liver, which is not reported, since these elements are frequently related to metabolic diseases affecting the liver. Most of the published work describes values from different regions of the world from healthy liver tissue post mortem, or from living individuals with liver disease. The objective of this study was to determine the concentration range for iron (Fe), copper (Cu), cadmium (Cd) and lead (Pb) in the healthy liver of living humans from northwestern Argentina by atomic absorption spectrometry. Liver tissue samples were digested by a microwave system using a previously optimised program. Quantification was performed by atomic absorption spectrometry using the flame atomisation technique for Fe, and electrothermal vaporisation for Cu, Cd and Pb. The respective techniques were validated. The concentration ranges obtained, in μg/g dry weight, were: Fe (322–1349), Cu (6.66-34.8), Cd (0.221-6.18), and Pb (0.340-23.8). The values recorded in this work differ from those published by various authors, probably due to the conditions of the liver tissue, post mortem in some cases, or from living individuals with diseased liver in others. These results could be a contribution to establish reference ranges of essential and non-essential trace elements in liver tissue for the region studied.

Keywords : Atomic absorption spectrometry; Trace elements; Liver.

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