Abstract

MERLO, W.A et al. Determinación de receptores de estrógeno beta en carcinomas mamarios caninos. Rev. vet. [online]. 2013, vol.24, n.1, pp.10-13. ISSN 1669-6840.

This work aims to communicate the determination of estrogen receptor beta (ERβ) in mammary tumors of 34 canine patients whose evolution after eighteen months post surgery was known. Its presence was associated with clinical staging of patients, histological type, histological grading of the malignancy, and evolution. Immunostaining was performed by biotin-streptavidin-peroxidase system. Positive ERβ immunostaining was observed in nuclei of carcinoma cells, myoepithelial cells and chondrocites. It was determined the percentage of nuclei immunolabeled according to histological type (simple carcinoma: 51%, complex carcinoma: 61%, mixed carcinoma: 63%), histologic grade of malignancy (GHI: 60% and GHII: 61%), the clinical stage (ECI: 68%, ECII: 56%, ECIII: 59%, ECIV: 58% and ECV 58%) and in accordance with survival at 18 months (live: 61% and dead: 60%). These results show higher percentages in groups of better prognosis (although no significant differences were established) in coincidence with the opinions expressed by others, except in reference to the histological grade of malignancy. These conflicting data suggest that further analysis to assess ERβ prognostic potential in canine mammary tumors is needed.

Keywords : Dog; Mammary neoplasms; Estrogen receptor beta; Immunohistochemistry.

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