Abstract

BARBERO, MR; SABAN, M; LEAL REYNA, M  and  LUTFI, RJ. Lymphocytic Hypophysitis: Pathophysiology and Utility of Anti-Pituitary Antibodies for Diagnosis. Rev. argent. endocrinol. metab. [online]. 2013, vol.50, n.2, pp.99-104. ISSN 1851-3034.

Lymphocytic hypophysitis (HL) is an autoimmune condition characterized by diffuse lymphocytic infiltration of the pituitary gland with varying degrees of destruction. It occurs mainly in young women during pregnancy or the postpartum period secondary to elevated levels of prolactin (PRL) associated with a drop in estrogen levels in the postpartum period. The antigen involved in its pathogenesis is still unknown. In recent years, the existence of antipituitary antibodies (APA) has been investigated to allow a simple, accurate diagnosis, with acceptable sensitivity and specificity that enables an adequate clinical interpretation and treatment.

Keywords : Lymphocytic hypophysitis; Autoinmunity; Antipituitary antibodies.

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