Abstract

PERNA, Eduardo R. Utilidad de los marcadores serológicos en el diagnóstico y estratificación de riesgo de la insuficiencia cardíaca. Insuf. card. [online]. 2007, vol.2, n.2, pp.55-61. ISSN 1852-3862.

The evaluation of patients with suspicion of heart failure (HF) has two main objectives: early diagnosis and concurrently, identification of low- and high-risk subjects. Despite HF is a highly prevalent condition, limitations in diagnosis, monitoring and risk stratification may be present. In this paper, the usefulness of natriuretic peptides (NP) and cardiac troponin (Tn) in chronic and decompensated HF is revisited. NP (BNP and NT-ProBNP) contribute with the differential diagnosis, provide prognostic information and may guide the treatment. Tn elevation identifies patients with stable HF or admitted for worsening HF, with higher incidence of events. The hypothesis to be demonstrated is that the measurement of NP and Tn during admisión and before discharge in decompensated HF might simultaneously help to identifying patients with high-risk during hospitalization, to monitoring the response to treatment, to detecting deleterious effect of drugs, to evaluating pre-discharge status, and to stratifying long-term prognosis. During the ambulatory phase of chronic HF, the periodic determination of both biomarkers may be useful to early identification of subjects at risk of decompensation, or to select candidates to advanced therapeutic options.

Keywords : Biomarkers; Heart failure; Prognosis; BNP; NTproBNP; Troponin.

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