Abstract

LOURDES, Balcázar Hernández et al. Tertiaryhyperparathyroidism as a manifestation of bone mineral metabolismdisease in kidneytransplantrecipient: a diagnostic and therapeuticchallenge. Presentation of a clinical case. Rev. nefrol. dial. traspl. [online]. 2021, vol.41, n.1, pp.71-80. ISSN 2346-8548.

Tertiary hyperparathyroidism (THPT) is characterized by hypercalcemia and autonomous hyperparathyroidism in the context of persistent secondary hyperparathyroidism (SHPT). THPT is related with extraskeletal calcifications, calciphylaxis, fractures, bone pain, progressive loss of bone mineral density, nephrocalcinosis, lithiasis, kidney allograft dysfunction and rejection, neuropsychiatric alterations, cardiovascular disease, and high morbimortality. Subtotal parathyroidectomy is the gold standard for treatment, with high cure rates. We described a case of THPT as a manifestation of Bone Mineral Metabolism Disease after a successful kidney transplant, with an insidious evolution and severe bone damage, with an adequate response to subtotal parathyroidectomy. We evidenced that early diagnosis and treatment of THPT in kidney transplant recipients is essential to the diminution of comorbidities, the improvement of prognosis and the optimization of health resources.

Keywords : tertiary hyperparathyroidism; kidney transplantation; hypercalcemia; parathyroidectomy.

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