Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
Links relacionados
- Similares en SciELO
- uBio
Compartir
Revista argentina de microbiología
versión impresa ISSN 0325-7541versión On-line ISSN 1851-7617
Resumen
LOPARDO, Horacio A. et al. Beta-lactam antibiotics and viridans group streptococci. Rev. argent. microbiol. [online]. 2022, vol.54, n.4, pp.131-140. Epub 01-Dic-2022. ISSN 0325-7541. http://dx.doi.org/10.1016/j.ram.2022.06.004.
The aim of this review is to present an update on the susceptibility of viridans groupstreptococci (VGS) to -lactam antimicrobials, with emphasis on the Argentinean scenario. VGSare a heterogeneous group including five groups of species, each one exhibiting peculiar sus-ceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequentlynonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. InArgentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporinsand carbapenems are currently more effective in vitro than PEN against VGS. Mortality was asso-ciated to nonsusceptibility to PEN in at least two studies involving patients with bacteremiacaused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN suscepti-bility of the isolates. Vancomycin may be an alternative choice for treating endocarditis causedby PEN-resistant isolates (MIC 4 g/ml).
Palabras clave : Viridans groupstreptococci;Lactams; Resistance; Penicillin bindingproteins ;Endocarditis.