Resumo

SANTIAGO, Bruno Rivas; HERNANDEZ, Yamilé López; SANTIAGO, César Enrique Rivas  e  ALMANZA, Gretel Mendoza. Effect of atmospheric air pollution on the innate antimycobacterial immune response. Salud(i)Ciencia [online]. 2019, vol.23, n.5, pp.10-19. ISSN 1667-8682.  http://dx.doi.org/www.dx.doi.org/10.21840/siic/159560.

Indoor and outdoor air pollution has been considered a serious public health problem worldwide, and is associated annually with around 7 million deaths (4.8 million associated with outdoor air and 2.2 million indoor air). The main reasons for these deaths include: chronic obstructive pulmonary diseases, pneumonia, ischemic cardiopathy and lung cancer. In addition, epidemiological studies have associated exposure to this type of pollutants with a greater susceptibility to the development of infectious and non-infectious diseases. One of the most important infectious diseases is tuberculosis, which over the years has worsened with the emergence of resistant multi-drug strains, as well as with association with other diseases such as diabetes mellitus type 2 and the acquired immune deficiency syndrome (AIDS). In fact, despite efforts made by the World Health Organization to stop the epidemic, a large number of deaths (about 1.7 million worldwide) are still caused by this disease. In this review, a brief summary will be made of the effects of exposure to indoor and outdoor air pollution on the innate immune response against tuberculosis, and how these alterations could be linked to the development of pulmonary tuberculosis.

Palavras-chave : air pollution; tuberculosis; immunity; innate immunity; particulate matter, AIDS.

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