Resumo

BOGADO, F et al. Cambios clínicos, hemáticos y coagulativos consecuentes al aumento de anticuerpos en equinos productores de suero antiofídico. Rev. vet. [online]. 2013, vol.24, n.1, pp.3-9. ISSN 1669-6840.

The aim of this work consisted to study the clinical and hematological effects that included blood coagulation and antibody production of a group of three horses immunized for the production of monovalent serum against Bothrops alternatus venom, in order to correlate the results with the humoral immune response of the animals. The results showed that immunization of horses with the essayed protocol induce slight clinic alterations and discrete changes in some parameters of the hemogram. Results also showed variations in the neutralizing capacity of the serum on different venom components, particularly toxins that affect blood coagulation. Also, it was verified a direct relationship between the rate of white blood cells and serum immunoglobulin production. Furthermore, they also indicate that the three-month rest period may be considered as too long as it causes a marked decrease in antibody titles, losing the serum its neutralizing capacity to venom compounds. Nevertheless, after re-administration of venom horses provided a rapid reposition of anti-toxins against B. alternatus venom, tolerating high venom doses during this second period of immunization.

Palavras-chave : Horse; Immunization; Bothrops alternatus; Hemogram; Coagulation.

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