Resumo

SOLER ARIAS, Elber Alberto  e  CASTILLO, Víctor Alejandro. Luteinising hormone-dependent Cushing's syndrome. Rev. argent. endocrinol. metab. [online]. 2016, vol.53, n.1, pp.36-41. ISSN 1851-3034.

Luteinising hormone (LH) and human chorionic gonadotropin (hCG) can induce steroidogenesis, hyperplasia, and adrenal tumorigenesis through the stimulus of the constitutive LH receptor (R-LHCG) within the adrenal cortex. The pathophysiological mechanisms of luteinising hormone-dependent Cushing's syndrome are not completely understood, but the ontogenic relationship between the adrenal cortex and the gonads, with mutual participation of different genes, transcription factors and steroidogenic enzymes cited as a possible cause, is well-recognised. SCa-LH has been described in pregnant women, as a result of hCG stimulus, and in post-menopausal women, due to increased levels of LH, as well as in ferrets after gonadectomy.

Palavras-chave : Aberrant receptors; Adrenal adenoma; Macronodular adrenal hyperplasia; Human chorionic gonadotropin; Dog.

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