Resumo

CHAGAS, Luma Cipriano; MEIRELES DE DEUS, Maria do Socorro  e  PERON, Ana Paula. Cytotoxicity of the food additive annatto and turmeric . Acta toxicol. argent. [online]. 2014, vol.22, n.2, pp.69-75. ISSN 1851-3743.

This study aimed to evaluate the effect of food additives annatto and turmeric tip cells of Allium cepa roots in doses of 5 or 10 g in exposure times of 24 and 48 hours. A group of five onion bulbs was used for each dose. Each dose was first embedded in distilled water and then transferred to their respective doses. Cells were analyzed throughout the cell cycle, totaling 5000 for each control and exposure time. The obtained data were subjected to statistical analysis Chi-square (p <.05). From the results it was observed that the doses of turmeric and annatto had significant antiproliferative effect on the cell cycle of this test system. They also found a significant number of cellular aberrations in the two exposure times evaluated all doses studied. Therefore, under the conditions studied, annatto and turmeric proved cytotoxic and genotoxic.

Palavras-chave : Bixa orellana L; Curcuma longa L; Cell division; Cellular aberrations.