Resumo

MARKARIAN, María Fernanda; OJEDA, Adriana  e  URIARTE, Ana María. Creutzfeldt-Jakob disease by MRI: Cortical alteration as early sign disease. Rev. argent. radiol. [online]. 2008, vol.72, n.4, pp.409-414. ISSN 1852-9992.

A 59-year-old man with probable Creutzfeldt-Jakob disease was studied from early symptoms. The patients manifested mild cognitive impairment. The first magnetic resonance showed hiperintense signal cortical abnormalities in FLAIR sequence predominantly in left hemisphere, FSE T2 no showed abnormalities. In other resonance those abnormities were more significative and appeared head of the caudate nucleus abnormalities in FLAIR and Diffusion-weighted, the patients began with rapidly progressing impairment, visual disturbance, pyramidal and extrapyramidal signs, seizures, myoclonus and mutism. The third resonance revealed cortical and basal ganglia high signal intensity abnormalities and the patient transformed slowing EEG to biphasic and triphasic sharp-waves. Three months later news imagines showed atrophy and very high signal intensity in cortical and basal ganglia. In conclusion: FLAIR and Diffusion-weighted sequences may be more sensitivity that T2 sequence, may be an early diagnostic clue of Creutzfeldt-Jakob.

Palavras-chave : Creutzfeldt-Jakob disease; Cortical hiperintensity; MRI Diffusion.

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