Abstract

DUBNER, D. et al. Prognosis and bone marrow recovery indicators in bone marrow transplantation after total body irradiation. Medicina (B. Aires) [online]. 2002, vol.62, n.6, pp.555-561. ISSN 0025-7680.

Oxidative stress and reticulocyte maturity index (RMI) were studied in 27 patients who underwent bone marrow transplantation (BMT). Plasmatic lipoperoxide levels of those patients with unfavorable evolution were significantly increased on days 12-14 post-transplant (median 1.83 µM, range 0.78-5.82) compared with preconditioning levels (median 1.05 µM, range 0.36-1.84) (p <0.05). Patients with favorable evolution revealed significantly higher lipoperoxide levels during conditioning regime (median 1.42 µM, range 0.31-4.50) (p<0.05). Starting from the 3^rd post-transplant week a significant and continuous decrease was observed, with a  median of  0.77 µM (range 0.21-1.48  p<0.05) for the 3^rd, and a median of 0.60 µM (range 0.11-1.48 for the 4^th week (p<0.01). A significant increase in total antioxidant activity was observed  in the three patients who died up to the 35 days post-transplant. Recovery of bone marrow function was detected by RMI after a median time of 17 days (range 11-24) post-allogeneic transplantation. The threshold established for absolute neutrophil count was achieved after a median of 21 days (range 14-28) (p< 0.001). An increase of plasma lipoperoxides on days 12-14 post-transplant may be a predictive value of unfavourable evolution. RMI was the earlier indicator of engraftment in allogeneic BMT.

Keywords : Bone marrow transplantation; Radiation; Engraftment; Oxidative stress; Reticulocytes.

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