Medicina (Buenos Aires)
versión On-line ISSN 1669-9106
SANJUAN, Norberto A.. The paradox of polyomaviruses Lytic infection or tumor induction?. Medicina (B. Aires) [online]. 2004, vol.64, n.1, pp. 73-76. ISSN 1669-9106.
Murine polyomaviruses can produce lytic infections in mouse cell cultures or transform in vitro rat fibroblasts through a complex interaction with key cellular regulators. After infection of newborn mice, some strains of polyomavirus induce epithelial and mesenchymal tumors. It has been described that there is a direct relationship between viral dissemination in the mouse and tumor induction. However, at a single cell level lytic infection and transformation would not be able to coexist. The existence of 3 distinct cell populations in polyoma-induced tumors, classified according to the presence or absence of viral DNA and viral capsid protein VP-1 have been described. We have reported a fourth type of cell in the neoplasms, that can express the early and the late viral genes but do not allow virus assembly, probably due to underphosphorylation of VP-1. The mechanisms of polyoma intracellular migration and dissemination in the mouse are discussed, related to the virus ability of tumor induction.
Palabras clave : polyomavirus; tumors; VP-1; microtubules; receptor; assembly.