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Medicina (Buenos Aires)

versión On-line ISSN 1669-9106

Resumen

AMBROSIO, Ana M.; RIERA, Laura M.; SAAVEDRA, María del Carmen  y  SOTTOSANTI, María J.. Preclinical assay of Candid #1 vaccine against Argentine Hemorrhagic Fever made in Argentina. Medicina (B. Aires) [online]. 2005, vol.65, n.4, pp. 329-332. ISSN 1669-9106.

Candid #1 vaccine against Argentine Hemorrhagic Fever produced in USA versus lots of the same vaccine made in Argentina were compared in guinea pigs regarding safety, immunogenicity and protective efficacy against a challenge with pathogenic Junin virus. Lots Nº Exp 3, 7A and 8A of Argentine origin as well as lot TSI 5-1-92 from USA were inoculated in guinea pigs of 250-400 g in two consecutive assays. Ten animals inoculated with saline performed as normal controls in each experiment. Parameters studied were: a) temperature; b) body weight; c) neutralizing antibodies to Junin virus; d) response to viral challenge. Animals gained weight and remained normothermic up to the challenge. Guinea pigs that received Candid #1 from any manufacturer elicited neutralizing antibodies to Junin virus (titles from 40 to 81920) and survived to challenge whilst 8/10 animals died in each control group. Data presented demonstrated that Candid #1 vaccines from USA or Argentine manufacturers were equally safe, immunogenic and protective in guinea pigs.

Palabras llave : Argentine Hemorrhagic Fever; Argentine vaccine; preclinical assays.

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