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Medicina (Buenos Aires)

Print version ISSN 0025-7680On-line version ISSN 1669-9106


TAU, Cristina  and  RUSSO, Ricardo. Severe osteoporosis with vertebral crushes in juvenile dermatomyositis: Effect of oral alendronate therapy. Medicina (B. Aires) [online]. 2007, vol.67, n.1, pp.53-56. ISSN 0025-7680.

Glucocorticoids are  used  for the treatment of inflammatory and  autoimmune diseases, cancer, and in prevention of organ rejects. A frequent secondary effect of longterm treatment with corticoids  is the loss of bone mass, caused by several mechanisms: decrease in the intestinal calcium absorption,   increase of the renal calcium excretion at the distal renal tubule, suppressive effect on the osteoblast and also in  apoptosis of osteoclasts, inhibition in local production of IGF I (Insulin-like growth factor) and IGFBPs (binding  IGF I proteins necessary for bone metabolism), and decrease on osteocalcin production. Longterm treatment with corticoids is associated with osteoporosis and vertebral  fractures. To improve this condition, treatment with  bisphosphonates has been proposed. We present here a clinical case of a girl with dermatomyositis and severe osteoporosis with vertebral crushes, who responded well to oral bisphophonate treatment.

Keywords : Osteoporosis; Juvenile dermatomyositis; Alendronate.

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