Abstract

CHIURCHIU, Carlos et al. Usefulness of equations based on serum cystatin C concentration in the study of renal function. Medicina (B. Aires) [online]. 2007, vol.67, n.2, pp.136-142. ISSN 0025-7680.

Serum creatinine is an insensitive marker to identify early changes in glomerular filtration rate (GFR), for this reason alternative methods to estimate renal function result of great clinical importance. Forty-one patients were studied using creatinine clearance modified with cimetidina (Clcrc) as surrogate of GFR, cystatin C-based equations (i.e. Larsson and Hoek formulas), Cockroft-Gault and MDRD abbreviated equations. In the whole group, as well as in those patients with serum creatinine ≤1.2 mg/dl -but reduced renal function: Clcrc 62.01 ± 17.33 ml/min/1.73 m²-, Larsson and Hoek equations showed higher correlations and lower bias than creatinine-based formulas. Abbreviated MDRD equation showed good performance just in those patients with evident alteration of renal function (serum creatinine > 1.2 mg/dl).  We concluded that in patients with different stages of renal function, cystatin C-based equations detect reduction of renal function earlier than the serum creatinine-based formulas.

Keywords : C cystatin; Cimetidine; Renal function; MDRD equation; Larsson equation; Hoek equation.

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