Abstract

KAUFFMAN, Marcelo A. et al. Is tumor necrosis factor - 376a promoter polymorphism associated with susceptibility to multiple sclerosis?. Medicina (B. Aires) [online]. 2007, vol.67, n.5, pp.436-438. ISSN 0025-7680.

A single nucleotide polymorphism (SNP) at position -376 of the tumor necrosis factor á gene (TNFA) has been associated with susceptibility to multiple sclerosis (MS) in Spain. However, no association was found in populations from the USA and The Netherlands. Here we investigate the association between the TNFA - 376A SNP and MS susceptibility in Argentinean patients with MS. The A/G genotype was found in 4.4% of patients (n=90) and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23- 3.84). Thus, no significant differences in genotype and allele frequencies were found between healthy individuals and patients with MS in Argentina.

Keywords : Genetic risk; Multiple sclerosis; Single nucleotide polymorphism; Tumour necrosis factor.

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