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Medicina (Buenos Aires)

versión On-line ISSN 1669-9106


ROJAS BILBAO, Erica A. et al. Hematodermic CD4+ CD56+ neoplasm in childhood. Medicina (B. Aires) [online]. 2008, vol.68, n.2, pp. 147-150. ISSN 1669-9106.

Hematodermic CD4+ CD56+ neoplasm with plasmacytoid dendritic cell phenotype is a rare and aggressive neoplasm recently recognized by the WHO-EORTC classification. It generally appears in elderly adults, exceptionally in childhood. We present a 12-year-old girl with severe mental retardation, genetic clinical features and multiple nodular cutaneous lesions on legs and arms. Histologically the nodules showed diffuse dermal infiltrate of medium and small cells and expression of CD4, CD56, CD43, S100 and plasmacytoid dendritic markers: CD123, BDCA-2 under flow cytometry study. Peripheral blood and bone marrow were not involved. Clinical remission of cutaneous lesions was observed after two weeks of acute lymphoblastic leukemia therapy.

Palabras clave : Hematodermic neoplasm; CD4; CD56; CD123; BDCA-2; Plasmacytoid dendritic cell; Blastic NK-cell lymphoma.

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