Medicina (Buenos Aires)
versión On-line ISSN 1669-9106
ROJAS, Juan Ignacio; GONZALEZ, Sergio J.; PATRUCCO, Liliana y CRISTIANO, Edgardo. Role of T-regulatory cells in multiple sclerosis. Medicina (B. Aires) [online]. 2010, vol.70, n.1, pp. 79-86. ISSN 1669-9106.
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans.
Palabras clave : T-regulatory cells; Demyelinating disease; Multiple sclerosis; Experimental autoimmune encephalomyelitis.