Medicina (Buenos Aires)
versión impresa ISSN 0025-7680
LORENZANO MENNA, Pablo et al. Rho GTPases as therapeutic targets in cancer and other human diseases. Medicina (B. Aires) [online]. 2010, vol.70, n.6, pp. 555-564. ISSN 0025-7680.
Rho GTPases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases. The aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. We also address the role of Rho GTPases in the development of different human diseases such as cancer. Finally, we describe different experimental therapeutic strategies with Rho GTPases as molecular targets.
Palabras clave : Cell signaling; Cytoskeleton; Cell migration; Neurodegenerative diseases; Cancer.