Abstract

GEJMAN, Pablo V.  and  SANDERS, Alan R.. The etiology of schizophrenia. Medicina (B. Aires) [online]. 2012, vol.72, n.3, pp.227-234. ISSN 0025-7680.

Research conducted in recent years represents a new dawn of knowledge for the risk factors of schizophrenia, and genome-wide approaches have revolutionized the field of genetic mapping of schizophrenia. The aggregate genetic data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap (pleiotropy) of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia. The current and upcoming resequencing programs - both exomes (all exons) and full genomes - and genome-wide transcriptional analyses will allow a more thorough dissection of the molecular genetics of the disorder.

Keywords : Schizophrenia; Genetics; Genome; Etiology; SNP; CNV; Polygenic; GWAS; Epidemiology.

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