Medicina (Buenos Aires)
Print version ISSN 0025-7680
MAZZEI, Juan Antonio; ROCHER, Adriana E. and PALAORO, Luis. Value of sputum analysis in the management of inflammatory airway diseases. Medicina (B. Aires) [online]. 2012, vol.72, n.4, pp. 332-338. ISSN 0025-7680.
Cellular analysis of sputum either spontaneous or by induced sputum technique, has become a widespread tool for the evaluation and guidance of treatment of inflammatory diseases of the airway, primarily asthma, COPD and eosinophilic bronchitis. Induced sputum method is a validated, standardized and non-invasive technique, useful in patients with difficulties to expectorate. Its implementation is simple and cost effective. Numerous investigations have shown the effectiveness of basing treatment decisions on the inflammatory component of the airway by counting cells in sputum. Several studies have demonstrated that in patients with asthma, results of this analysis can guide in defining strategies to reduce exacerbations and to improve lung function even in patients with severe asthma, as well as to decrease the remodeling; in addition, a reduction in exacerbations in COPD patients, monitored by this sputum examination, has also been described.
Keywords : Cellular analysis of sputum; Asthma; Chronic obstructive pulmonary disease; Eosinophilic bronchitis; Chronic cough.