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Medicina (Buenos Aires)

Print version ISSN 0025-7680


CHAIO, Sebastián; TOIBARO, Javier; VALICENTI, Pedro  and  SAIDON, Patricia. Adverse drug reactions and prescription errors: morbi-mortality. Medicina (B. Aires) [online]. 2013, vol.73, n.2, pp.111-118. ISSN 0025-7680.

Pharmacovigilance aims to detect, assess, understand and prevent any possible drug-related problem. The record of information related to adverse drug reactions (ADRs) after drug approval and risk management based on observational data are crucial for public health. The main goal was to assess the ADRs morbimortality and to describe prescription medical errors in a public hospital in the city of Buenos Aires. A prospective observational study was undertaken. ADR was defined as any clinical and/or biological noxious manifestation imputable to a drug, which occurs at the usually used dose in humans for disease prophylaxis, diagnosis or treatment. Global mortality was 7% (21/310). The observed mortality due to ADR accounted for 1% (3/310). One hundred and forty nine ADRs in 36% of patients were identified (111/310), and 11% (35/310) of the hospital admissions were due to ADRs. ADRs cause a great number of admissions and are responsible for preventable morbidity during hospitalization. Neither drug alone caused more than 6% of the ADRs. For this reason, in order to diminish ADRs, strategies should be addressed to multiple drug groups.

Keywords : Adverse drug reactions; Pharmacovigilance; Drug prescription errors.

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