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Medicina (Buenos Aires)

versión impresa ISSN 0025-7680


MALBRAN, Alejandro; MALBRAN, Eloisa; MENENDEZ, Alejandra  y  FERNANDEZ ROMERO, Diego S.. Hereditary angioedema: Treatment of acute attacks in Argentina. Medicina (B. Aires) [online]. 2014, vol.74, n.3, pp.198-200. ISSN 0025-7680.

In the world, hereditary angioedema (HAE) affects 1every 50 000 persons. It is characterized by highly disabling and recurrent episodes of cutaneous, abdominal and laryngeal episodes of angioedema. Asphyxia related mortality ranges from 15 to 50%. In Argentina a plasma derived C1 inhibitor concentrate (pdC1INH) has been available for the treatment of acute attacks for many decades, however, only15 (26%) out of 58 patients had received pdC1INH at least once until 2008, and only2 (3.4%) had used it regularly. After worldwide approval of the new drugs for the treatment of acute HAE attacks, adding icatibant to pdC1INH in Argentina, and after publication of the therapeutic guide for the country, 42 (82%) out of 51 patients from the original group has pdC1INH available to treat their next attack. However, 16 (18%) patients continue without access to medication and other 15 (35.7%) obtain their therapy spuriously through some other affected relative in their environment. Only 12 (28.6%) patients of the group self-treated at home. Access to treatment has greatly improved, but needs to be extended to all patients and self-treatment at home should be encouraged.

Palabras clave : Hereditary angioedema; C1 inhibitor; Hereditary angioedema.

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