Abstract

DAL VERME, Agustín et al. Secreción ectópica de ACTH en un paciente con antecedentes de enfermedad de Cushing. Medicina (B. Aires) [online]. 2015, vol.75, n.4, pp.218-220. ISSN 0025-7680.

A 54-year-old man, with a history of Cushing’s disease diagnosed 32 years earlier, presented with edema, asthenia and general malaise. Abnormal laboratory studies depicted hypokalemia and metabolic alkalosis. A CT scan of the chest revealed a 3 × 3 cm tumor in the anterior mediastinum. The pathology was consistent with a thymic carcinoid. These findings led to a diagnosis of biochemical Cushing’s syndrome secondary to ectopic secretion of ACTH. Thus, this patient suffered twice of Cushing’s syndrome. The first instance was the consequence of an ACTH - secreting pituitary adenoma and the second of an ectopic secretion of ACTH. To the best of our knowledge this is the first such case reported in the medical literature.

Keywords : Cushing’s disease; Ectopic secretion of ACTH; Thymic carcinoid.

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