Abstract

FUENTE, Graciela V et al. Insulinización en la diabetes mellitus tipo 2: Alternativas de intensificación. Medicina (B. Aires) [online]. 2016, vol.76, n.3, pp.173-179. ISSN 0025-7680.

Diabetes mellitus is associated with vascular complications and high rates of morbidity and mortality. Timely insulin therapy, intensified when necessary, represent appropriate measures to prevent or delay the onset of complications. However, the incidence of hypoglycemia and difficulties in treatment adherence represent barriers to achieve therapeutic success. Premixes analogs and, specially, combinations of insulin analogues are associated with pharmacokinetic and pharmacodynamic advantages, that translate into clinical benefits such as improved metabolic control, decreased hypoglycemic events and, for their simplicity, potentially greater adherence.

Keywords : Insulin; Combination drugs; Aspart insulin; Degludec insulin; Insulin-therapy; Biphasic insulin.

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