Abstract

REY DEUTSCH, Ana C et al. Tratamiento de meningitis tuberculosa en paciente HIV negativo, posible reacción paradojal. Medicina (B. Aires) [online]. 2017, vol.77, n.2, pp.126-128. ISSN 0025-7680.

The paradoxical response to tuberculosis treatment consists in the appearance of new clinical or radiologic manifestations or worsening of previous injuries after an initial improvement with anti-tuberculosis therapy. It can be observed in 6 to 30 percent of the cases of tubercular meningitis. It is the consequence of an exaggerated immune reaction that should be considered since the treatment is based on the use of immunomodulators and not in the change of anti-tuberculous drugs. We present the case of an HIV negative adult with tuberculous meningitis with a good initial response to specific therapy who showed, 10 weeks later, a paradoxical reaction to treatment that responded successfully to corticosteroids.

Keywords : Tubercular meningitis; Paradoxical reaction; Corticosteroids.

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