Abstract

COSTAS, Mónica A  and  RUBIO, María F.. Autofagia, una estrategia de supervivencia celular. Medicina (B. Aires) [online]. 2017, vol.77, n.4, pp.314-320. ISSN 0025-7680.

Autophagy is a process of recycling parts of the cell. As described in this review, it occurs naturally in order to preserve cells from the accumulation of toxins, damaged molecules and organelles, and to allow processes of tissue development and differentiation. In the course of autophagy, the processing of the substrates to be recycled generates ATP, thus providing an alternative source of energy in stress situations. In this sense, under hostile conditions such as hypoxia or lack of nutrients, the autophagy process can be exacerbated leading to cell death. Some alterations in its functioning may involve the development of various pathologies, including liver damage, cancer and neurodegenerative diseases.

Keywords : Autophagy; mTOR; Cell survival.

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