Abstract

MAGGIO, Julián; GONZALEZ, Nazareno; CARDAMA, Georgina A  and  GOMEZ, Daniel E. RHO GTPasas como blancos moleculares en cáncer: Estrategias y oportunidades terapéuticas. Medicina (B. Aires) [online]. 2017, vol.77, n.6, pp.497-504. ISSN 0025-7680.

Rho GTPases are molecular switches that control the different cellular processes. Deregulation of these proteins is associated to transformation and malignant progression in several cancer types. Given the evidence available of the role of Rho GTPases in cancer it is suggested that these proteins can serve as potential therapeutic targets. This review focuses on the strategies used to develop Rho GTPases modulators and their potential use in therapeutic settings.

Keywords : Rho GTPases; Cancer; Molecular target.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )