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Medicina (Buenos Aires)

Print version ISSN 0025-7680On-line version ISSN 1669-9106


COLLADO, María Victoria et al. Dermatomiositis asociada al autoanticuerpo anti-MDA5. Medicina (B. Aires) [online]. 2018, vol.78, n.5, pp.360-363. ISSN 0025-7680.

Dematomyositis is an idiopathic inflammatory myopathy with a variable clinical spectrum. In recent years, a number of myositis-specific antibodies have been identified including anti-MDA5, which is us eful for diagnosis, prognosis and classification of the diverse clinical forms of the disease. This antibody is associated with cutaneous ulcers, rapidly progressive interstitial lung disease, early mortality and poor prognosis, so the detection of this antibody in a suitable clinical context, raises the need for an aggressive immunosuppressive treatment. We describe a case of dermatomyositis classified as hypomyopathic (i.e. involving mild muscle weakness), presenting specific skin lesions, interstitial lung disease, and presence of anti-MDA5 antibody that had a favorable response to combined treatment with cyclophosphamide, gamma globulin and corticosteroids.

Keywords : Dermatomyositis; Melanoma differentiation associated protein-5; Autoantibodies; Interstitial lung disease.

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