Abstract

PAVIOLO, Juan Pablo; IMBACH, María Celeste; NOCENTI, Zulma A  and  DURAND, Bruno L. Rapidly progressive dementia due to neurosyphilis (general paralysis). A treatable case of dementia. Medicina (B. Aires) [online]. 2020, vol.80, n.4, pp.401-404. ISSN 0025-7680.

Rapidly progressive dementias are conditions of impairment in more than one cognitive domain with functional compromise that progress in less than 1 to 2 years; and neurosyphilis is one of the etiologies. Syphilis is a chronic bacterial infection that causes a series of highly variable clinical conditions during the first 2 to 3 years, followed by a prolonged latent stage that can progress to a tertiary infection stage. After a period of years, or even decades, a third of people with untreated latent syphilis will have clinical manifestations of tertiary syphilis such as neurosyphilis. We present the case of a 41-year-old man who consulted for prostration symptoms, preceded by progressive behavioral cognitive alterations of 18 months of evolution. A dementia picture was found associated with pharmacological parkinsonism secondary to risperidone, so this treatment was suspended. Neuroimaging showed severe cerebral atrophy; serum and cerebrospinal fluid (CSF) reactive VDRL, in addition to a slight increase in CSF proteins. The diagnosis of late neurosyphilis was made and treated with crystalline penicillin G 1 400 000 IU every 4 h for 14 days with an excellent response. Our case allows us to reflect on the importance of requesting diagnostic studies of syphilis in young patients who present a rapidly evolving dementia, since this disease has a treatment that can partially or totally reverse the symptoms.

Keywords : Syphilitic dementia; Rapidly progressive dementia; Neurosyphilis; General paralysis; Tertiary syphilis; Treponema pallidum.

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