Resumen

ROFFO, Alejandra Gonzalez et al. Immunohistochemical analysis for the diagnosis of solitary fibrous tumor/hemangiopericytoma. Medicina (B. Aires) [online]. 2020, vol.80, n.6, pp.729-733. ISSN 0025-7680.

The solitary fibrous tumor/ hemangiopericytoma (TFS/HP) is a rare mesenchymal extraaxial tumour. TFS/HP can sometimes be difficult to distinguish from other extra-axial tumors like meningioma, which can be clinically and radiologically indistinguishable. Molecular analysis with STAT6 (signal transducer and activator of transcription 6) nuclear expression or NAB2-STAT6 (NGFI-A binding protein 2) fusion is recommended to confirm the diagnosis. We present 3 cases, 2 women and 1 male, with pathological diagnosis of meningothelial meningioma in the first case; cases 2 and 3 with radiological suspicion of meningioma. The pathological review with molecular study certified the diagnosis of TFS/HP. For differential diagnosis between meningeal TFS/HP and meningioma, it is recommended to look for STAT6 expression as a first step, or NAB2-STAT6 fusion in order to confirm TFS/HP. The review of biopsy samples must be guaranteed in all patients, including those who were studied in Pathology Services Level 3.

Palabras clave : Immunohistochemistry; Meningioma; STAT6 protein; Solitary fibrous tumor; Hemangiopericytoma.

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