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Medicina (Buenos Aires)

Print version ISSN 0025-7680On-line version ISSN 1669-9106


PANKL, Sonia et al. Whipple’s disease and reversible pulmonary hypertension. Medicina (B. Aires) [online]. 2021, vol.81, n.1, pp.91-95. ISSN 0025-7680.

Whipple’s disease is a chronic mutisystem disease caused by the bacteria Tropherima whipplei. Approximately 1200 cases have been described in the literature. The worldwide incidence is estimated at 9.8 cases per million people. Data from South America and Europe show that it affects middle-aged males. It is believed that host immunological factors rather than agent genotypic traits influence the course of the infection. Since the clinical characteristics are usually nonspecific and the wide spectrum of manifestations in individual organs may be underestimated, the diagnosis remains challenging. We present a case with multisystem compromise confirmed by histopathology. We consider its publication important given the few cases documented in South America and the relevance of bearing in mind the importance of an early diagnosis for a prompt treatment that improves the prognosis of this rare disease.

Keywords : Whipple’s disease; Tropheryma whipplei; Histopathology.

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