SciELO - Scientific Electronic Library Online

vol.82 suppl.1Estabilidad diagnóstica de niños con trastorno del espectro autista en la adolescencia (TEA). Funcionamiento ejecutivo, socio-adaptativo y conductualIntervenciones tecnológicas adaptativas para el trastorno del espectro autista: una revisión bibliográfica índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Medicina (Buenos Aires)

versión impresa ISSN 0025-7680versión On-line ISSN 1669-9106


RUGGIERI, Víctor  y  ARBERAS, Claudia. Epigenetic mechanisms involved in the genesis of autism. Medicina (B. Aires) [online]. 2022, vol.82, suppl.1, pp.48-53. ISSN 0025-7680.

Autism is a neurobiological developmental disorder characterized by poor social interaction and communication, narrow interests, and stereotyped behaviors. It has been associated with disorders of synaptogenesis and multiple etiologies. The iden tification of the epigenetic factors involved in the genesis of autism allows a better understanding of the molecular mechanisms involved. Our objective was to analyze the epigenetic mechanisms related to the development of autism, specifying specific entities and their pathophysiological mechanisms. We analyze how DNA methylation disorders, histone modification, remodeling and chromosomal regulation mediated by non-coding RNA are related to various genetic syndromes such as fragile X, Rett, Pathias Mecp2, Phelam McDermid, prenatal toxins such as alcohol, valproic. acid, cannabis, and environmental toxins such as maternal stress, all associated with a higher prevalence of autism. In conclusion: the recognition of these mechanisms opens up new possibilities for preven tion and it is likely that, in genetic entities, it will allow the development of specific treatments with modifications tailored to each entity.

Palabras clave : Autism; Epigenetics; Rett syndrome; Fragil X syndrome; Phelam McDermid syndrome; Fetal valpoic syndrome.

        · resumen en Español     · texto en Español     · Español ( pdf )