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Medicina (Buenos Aires)

Print version ISSN 0025-7680On-line version ISSN 1669-9106


PERRI, Marcella et al. Stiff person syndrome associated with thymoma. Medicina (B. Aires) [online]. 2023, vol.83, n.4, pp.626-630. ISSN 0025-7680.

Stiff-person syndrome is a rare neurological condi tion characterized by muscular rigidity of the trunk and extremities and muscle spasms triggered by sensory or emotional stimuli, which progresses towards prostra tion. It has a pathophysiogenic mechanism with an immunological basis, in which autoantibodies, such as antiGAD65, play a central role. Likewise, the detec tion of these antibodies corroborates the diagnosis in a patient with a suggestive clinical picture. Four to 6% of cases have underlying neoplasms. Treatment is based on symptomatic, immunomodulatory, and underlying disease management in paraneoplastic cases. We re port a case of classic stiff person syndrome associated with thymoma and review the main characteristics of this entity.

Keywords : Stiff person syndrome; Thymoma; Para neoplastic syndrome; Autoantibodies.

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