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Medicina (Buenos Aires)

Print version ISSN 0025-7680On-line version ISSN 1669-9106


BENITEZ CRUZ, Agustina et al. Diabetic ketoacidosis secondary to immunotherapy. Medicina (B. Aires) [online]. 2024, vol.84, n.1, pp.138-142. ISSN 0025-7680.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that are increasingly used in cancer treat ments. As experience in the use of immunotherapy increases, more is known about its safety profile and immune-mediated adverse effects. Among them is dia betic ketoacidosis (DKA), a rare but serious fatal compli cation of treatment. In this paper we describe the cases of three patients who presented with episodes of DKA during treatment with ICIs, two of which manifested with fulminant forms, leading to an acute course with initially normal glycosylated hemoglobin values. In ad dition, we conducted a review of the literature on DKA associated with ICIs in order to highlight the importance of noticing these potentially fatal complications and promptly establishing appropriate therapy.

Keywords : Diabetic ketoacidosis; Immunotherapy; Immune checkpoint inhibitors; Fulminant diabetes.

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