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Archivos argentinos de pediatría

versión On-line ISSN 1668-3501


GOLDSMIT, Gustavo et al. Indometacina: dosis administrada versus dosis indicada. Arch. argent. pediatr. [online]. 2006, vol.104, n.1, pp. 10-14. ISSN 1668-3501.

Introduction. Indomethacin is frequently used for the pharmacological ductus closure in premature infants. In Argentina the commercial form of indomethacin (IM 75® 50 mg/2 cc) has to be diluted twice to reach the neonatal dose. Objective. To assess whether the dose of indomethacin delivered in a NICU is equivalent to the theoretical indicated dose. Population, material and methods. 50 NICU nurses at Hospital de Pediatría J. P. Garrahan were selected random sampling; they prepared the standard solution of the drug for a hypothetical 1,000 grs newborn (0.2 mg/k). Two series of 50 samples were prepared corresponding to the following dilutions: 0.5 mg/cc and 0.2 mg/12 cc. Each sample was analyzed by high performance liquid chromatography. We compared the theoretical ordered dose with the concentration obtained by dilution. Paired t test was used for analysis. Results. For the intermediate dilution (0.5mg/cc) we observed a medium concentration of 0.64 mg/cc (CI 95% 0.59-0.68), and for the final dilution (0.2 mg/12 cc), it was 0.28 mg (CI 95% 0.26-0.30). These differences were statistically significant; 66% (33/ 50) of the final dilution samples surpassed in more of 20% the concentration indicated (0.2mg/12 cc). Conclusions. After dilution, the actual dose of indomethacin for delivering is not equivalent to the indicated one. In most cases, the delivered doses surpassed widely the theorical indicated.

Palabras clave : Indomethacin; Delivered dose; Dilution.

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