Abstract

HIRSCHLER, Valeria et al. Síndrome metabólico en la infancia y su asociación con insulinorresistencia. Arch. argent. pediatr. [online]. 2006, vol.104, n.6, pp.486-491. ISSN 0325-0075.

Objective. Metabolic syndrome is associated with insulin-resistance in adults. We defined pediatric metabolic syndrome using criteria analogous to ATPIII. The purpose of this study was to determine if these criteria are reliable for insulin-resistance in children. Population, materials and methods. 167 children with an average age of were evaluated (6.7±3 years); 73 with overweight (BMI >95^th percentile), 41 at risk of overweight (BMI >85 <95^th percentile), and 53 with normal weight (BMI <85^th percentile) matched for sex and age. The results for waist circumference, blood pressure, OGTT, C-reactive protein (CRP), adiponectin, insulin and lipids were obtained. Results. There was a comparable prevalence of metabolic syndrome in both sexes. The prevalence of the metabolic syndrome was 11.3% (95% CI 6.56% to 16.19%) among the whole group and 21.9% (95% CI 12.24% to 31.0%) among overweighted children. Risk factors as waist circumference >75^th percentile in 53.2% (95% CI 45.73% to 60.86%), and low HDL in 27.5% (95% CI 20.77% to 34.32%), were common in this sample. Compared with patients without any component of the metabolic syndrome, HOMA-IR for patients with one to four components was higher (Beta= 0.6; 95% CI, 0.4 - 0.7; P< 0.0001; R²= 0.185). A logistic regression analysis using the metabolic syndrome as the dependent variable showed that HOMA-IR (OR: 1.52; 95%CI, 1.2 - 2.0; P= 0.007) was the only independent risk factor significantly associated the metabolic syndrome, adjusted for age and sex. Conclusion. The importance of insulin-resistance in the metabolic syndrome is supported by the results of logistic-regression analysis. Early identification of children with metabolic syndrome may be useful to predict future cardiovascular disease and type 2 diabetes.

Keywords : Metabolic syndrome; Insulin-resistance; Waist circumference; Cardiovascular disease; Obesity.

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