Abstract

LIERN, Miguel; MALDONADO, Laura; JORDAN, Pablo  and  VALLEJO, Graciela. Efficacy of Enalapril in patients with single kidney and with or without normoprotein diet. Arch. argent. pediatr. [online]. 2008, vol.106, n.5, pp.416-421. ISSN 0325-0075.

Introduction. The patient with a solitary kidney and free protein intake can present pathological microalbuminuria. Objective. To evaluate the efficacy of Enalapril in patients with single kidney and with or without normoprotein diet. Materials and methods. We studied 49 patients, mean age 11 years, eutrophics, with normal renal function and with approved medical consent. The exclusion criteria were: uropathies, arterial hypertension, malignant diseases, orthostatic proteinuria and previous treatments with nephrotoxics drugs. Patients were classified in two groups: Group A: with normoprotein diet (0.8 to 1.2 g/kg/day). Group B: with free protein intake. The patients with abnormal microalbuminuria received Enalapril (doses between 0.1-0.3 mg/kg/ day). Results. Group A: 21 patients, 2 with abnormal microalbuminuria. Mean increase of the renal size 14% (SD 8), risk of presenting pathological microalbuminuria: 9%. Group B: 28 patients, 11 with pathological microalbuminuria. Mean increase of the renal size: 33.8% (SD 6.1), risk of presenting abnormal microalbuminuria: 40%. RR: 4.125 (CI 1-16) (p: 0.01). NND: 3. Mean range of microalbuminuria pre- Enalapril 50 µg/min and post-Enalapril 11 µg/ min. Mean doses of Enalapril: 0.2 mg/kg/day. Correlation coefficient between increase of renal size and microalbuminuria range: 0.75 and between increase renal size and protein intake: 0.72. Mean time to reach abnormal microalbuminuria: 81 months (DS 7). Conclusion. Enalapril together with the normoprotein diet in patient with single kidney reduces the risk of developing abnormal microalbuminuria.

Keywords : Single kidney; Microalbuminuria; Normoprotein diet; Enalapril.

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