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Archivos argentinos de pediatría

Print version ISSN 0325-0075On-line version ISSN 1668-3501


MASPERO, Jorge F. et al. Chronic autoimmune urticaria: treatment with omalizumab. Arch. argent. pediatr. [online]. 2009, vol.107, n.5, pp.452-456. ISSN 0325-0075.

We report the case of a child with diagnosis of chronic urticaria/angioedema and its evolution upon omalizumab treatment. Case report. Our patient is a 12-years-old female who suffered for 14 months severe chronic urticaria/angioedema. She had a poor response to the highest doses of combined therapy with 3 antihistamines, steroids and anti-leukotrienes and great impairment of her quality of life. An autologous serum skin test was positive until 1:100 dilutions, leading to the diagnosis of chronic autoimmune urticaria. Due to the lack of response to treatment, therapy with omalizumab was administered. A notable reduction in symptoms toward the third dose was observed. After 12 months of this treatment, the patient is asymptomatic and has a negative autologous serum test. Conclusion. Omalizumab could be a therapeutic option for patients with autoimmune urticaria unresponsive to other treatments.

Keywords : Urticaria; Autoimmune; Omalizumab; Children.

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